The Enzyme Database

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EC 4.99.1.11     
Accepted name: sirohydrochlorin nickelchelatase
Reaction: Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+
Other name(s): cfbA (gene name)
Systematic name: Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Comments: The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Zheng, K., Ngo, P.D., Owens, V.L., Yang, X.P. and Mansoorabadi, S.O. The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. Science 354 (2016) 339–342. [PMID: 27846569]
[EC 4.99.1.11 created 2017]
 
 


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