The Enzyme Database

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Accepted name: ferrochelatase
Reaction: protoheme + 2 H+ = protoporphyrin + Fe2+
For diagram of heme and chlorophyll biosynthesis, click here
Other name(s): ferro-protoporphyrin chelatase; iron chelatase; heme synthetase; heme synthase; protoheme ferro-lyase
Systematic name: protoheme ferro-lyase (protoporphyrin-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9012-93-5
1.  Bloomer, J.R., Hill, H.D., Morton, K.O., Anderson-Burnham, L.A. and Straka, J.G. The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase. J. Biol. Chem. 262 (1987) 667–671. [PMID: 3805002]
2.  Porra, R.J. and Jones, O.T. Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract. Biochem. J. 87 (1963) 181–185. [PMID: 13972328]
3.  Porra, R.J. and Jones, O.T. Studies on ferrochelatase. 2. An investigation of the role of ferrochelatase in the biosynthesis of various haem prosthetic groups. Biochem. J. 87 (1963) 186–192. [PMID: 13972329]
[EC created 1965]

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