The Enzyme Database

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EC 4.6.1.2     
Accepted name: guanylate cyclase
Reaction: GTP = 3′,5′-cyclic GMP + diphosphate
For diagram of GTP biosynthesis, click here
Other name(s): guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing)
Systematic name: GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming)
Comments: Also acts on ITP and dGTP.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9054-75-5
References:
1.  Garbers, D.L., Suddath, J.L. and Hardman, J.G. Enzymatic formation of inosine 3′,5′-monophosphate and of 2′-deoxyguanosine 3′,5′-monophosphate. Inosinate and deoxyguanylate cyclase activity. Biochim. Biophys. Acta 377 (1975) 174–185. [PMID: 235291]
2.  Hardman, J.G. and Sutherland, E.W. Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3′,5′-monophosphate from guanosine triphosphate. J. Biol. Chem. 244 (1969) 6363–6370. [PMID: 4982201]
[EC 4.6.1.2 created 1972]
 
 


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