The Enzyme Database

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EC 4.6.1.16     
Accepted name: tRNA-intron lyase
Reaction: pretRNA = a 3′-half-tRNA molecule with a 5′-OH end + a 5′-half-tRNA molecule with a 2′,3′-cyclic phosphate end + an intron with a 2′,3′-cyclic phosphate and a 5′-hydroxyl terminus
Other name(s): transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease
Systematic name: pretRNA lyase (intron-removing; cyclic-2′,3′-phosphate-forming)
Comments: The enzyme catalyses the final stage in the maturation of tRNA molecules.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 117444-13-0
References:
1.  Attardi, D.G., Margarit, I. and Tocchini-Valentini, G.P. Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease. EMBO J. 4 (1985) 3289–3297. [PMID: 3937725]
2.  Peebles, C.L., Gegenheimer, P. and Abelson, J. Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease. Cell 32 (1983) 525–536. [PMID: 6186398]
3.  Thompson, L.D., Brandon, L.D., Nieuwlandt, D.T. and Daniels, C.J. Transfer RNA intron processing in the halophilic archaebacteria. Can. J. Microbiol. 35 (1989) 36–42. [PMID: 2470486]
4.  Thompson, L.D. and Daniels, C.J. A tRNA(Trp) intron endonuclease from Halobacterium volcanii. Unique substrate recognition properties. J. Biol. Chem. 263 (1988) 17951–17959. [PMID: 3192521]
[EC 4.6.1.16 created 1992 as EC 3.1.27.9, transferred 2014 to EC 4.6.1.16]
 
 


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