The Enzyme Database

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EC 4.4.1.26     
Accepted name: olivetolic acid cyclase
Reaction: 3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate
For diagram of cannabinoid biosynthesis, click here
Glossary: 2,4-dihydroxy-6-pentylbenzoate = olivetolate
Other name(s): OAC
Systematic name: 3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming)
Comments: Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Gagne, S.J., Stout, J.M., Liu, E., Boubakir, Z., Clark, S.M. and Page, J.E. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proc. Natl. Acad. Sci. USA 109 (2012) 12811–12816. [PMID: 22802619]
[EC 4.4.1.26 created 2012]
 
 


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