The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 184.108.40.2064, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway.
Goenrich, M., Bartoschek, S., Hagemeier, C.H., Griesinger, C. and Vorholt, J.A. A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy. J. Biol. Chem.277 (2002) 3069–3072. [DOI] [PMID: 11741920]
[EC 220.127.116.11 created 2005 (EC 18.104.22.168 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 22.214.171.124)]