| EC |
4.4.1.22 |
| Accepted name: |
S-(hydroxymethyl)glutathione synthase |
| Reaction: |
S-(hydroxymethyl)glutathione = glutathione + formaldehyde |
| Other name(s): |
glutathione-dependent formaldehyde-activating enzyme; Gfa; S-(hydroxymethyl)glutathione formaldehyde-lyase |
| Systematic name: |
S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming) |
| Comments: |
The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 425642-27-9 |
| References: |
| 1. |
Goenrich, M., Bartoschek, S., Hagemeier, C.H., Griesinger, C. and Vorholt, J.A. A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy. J. Biol. Chem. 277 (2002) 3069–3072. [DOI] [PMID: 11741920] |
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| [EC 4.4.1.22 created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 4.4.1.22)] |
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