Requires Mg2+. The enzyme gives 28% cubebol, 29% (-)-germacrene D, 10% (+)-δ-cadinene and traces of several other sesquiterpenoids. See also EC 188.8.131.52 (–)-germacrene D synthase and EC 184.108.40.206 (+)-δ-cadinene synthase.
Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. Chembiochem.11 (2010) 1093–1106. [DOI] [PMID: 20419721]