The Enzyme Database

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EC 4.2.3.70     
Accepted name: patchoulol synthase
Reaction: (2E,6E)-farnesyl diphosphate + H2O = patchoulol + diphosphate
For diagram of guaiene, α-gurjunene, patchoulol and viridiflorene biosynthesis, click here
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Croteau, R., Munck, S.L., Akoh, C.C., Fisk, H.J. and Satterwhite, D.M. Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations. Arch. Biochem. Biophys. 256 (1987) 56–68. [PMID: 3038029]
2.  Munck, S.L. and Croteau, R. Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin. Arch. Biochem. Biophys. 282 (1990) 58–64. [PMID: 2171435]
3.  Faraldos, J.A., Wu, S., Chappell, J. and Coates, R.M. Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-2H1]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. J. Am. Chem. Soc. 132 (2010) 2998–3008. [PMID: 20148554]
[EC 4.2.3.70 created 2011]
 
 


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