The Enzyme Database

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EC 4.2.3.56     
Accepted name: γ-humulene synthase
Reaction: (2E,6E)-farnesyl diphosphate = γ-humulene + diphosphate
For diagram of humulene-based sequiterpenoid biosynthesis, click here
Other name(s): humulene cyclase
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (γ-humulene-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 110639-19-5
References:
1.  Steele, C.L., Crock, J., Bohlmann, J. and Croteau, R. Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of δ-selinene synthase and γ-humulene synthase. J. Biol. Chem. 273 (1998) 2078–2089. [PMID: 9442047]
2.  Little, D.B. and Croteau, R.B. Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases δ-selinene synthase and γ-humulene synthase. Arch. Biochem. Biophys. 402 (2002) 120–135. [PMID: 12051690]
[EC 4.2.3.56 created 2011]
 
 


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