The Enzyme Database

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EC 4.2.3.39     
Accepted name: epi-cedrol synthase
Reaction: (2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate
For diagram of bisabolene-derived sesquiterpenoid biosynthesis, click here
Other name(s): 8-epicedrol synthase; epicedrol synthase
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming)
Comments: The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins α-cedrene, β-cedrene, (E)-β-farnesene and (E)-α-bisabolene [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
References:
1.  Mercke, P., Crock, J., Croteau, R. and Brodelius, P.E. Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L. Arch. Biochem. Biophys. 369 (1999) 213–222. [PMID: 10486140]
2.  Hua, L. and Matsuda, S.P. The molecular cloning of 8-epicedrol synthase from Artemisia annua. Arch. Biochem. Biophys. 369 (1999) 208–212. [PMID: 10486139]
[EC 4.2.3.39 created 2009]
 
 


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