Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration . In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 22.214.171.124, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone .
Lin, X., Hopson, R. and Cane, D.E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J. Am. Chem. Soc.128 (2006) 6022–6023. [DOI] [PMID: 16669656]
Zhao, B., Lin, X., Lei, L., Lamb, D.C., Kelly, S.L., Waterman, M.R. and Cane, D.E. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J. Biol. Chem.283 (2008) 8183–8189. [DOI] [PMID: 18234666]