EC	4.2.3.229
Accepted name:	ent-beyerene synthase
Reaction:	ent-copalyl diphosphate = ent-beyerene + diphosphate
Glossary:	ent-beyerene = ent-beyer-15-ene = beyer-15-ene
Other name(s):	ent-kaurene synthase like 2; RcKSL4; OsKSL2; PpCPS/KS (ambiguous)
Systematic name:	ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-beyerene-forming)
Comments:	The enzyme has been shown to occur in castor bean (Ricinus communis) and rice (Oryza sativa). ent-Beyerene is also a product of EC 4.2.3.19 (ent-kaurene synthase) of the moss Physcomitrella patens.
References:	1.  Jackson, A.J., Hershey, D.M., Chesnut, T., Xu, M. and Peters, R.J. Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization. Phytochemistry 103 (2014) 13–21. [PMID: 24810014] 2.  Tezuka, D., Ito, A., Mitsuhashi, W., Toyomasu, T. and Imai, R. The rice ent-kaurene synthase like 2 encodes a functional ent-beyerene synthase. Biochem. Biophys. Res. Commun. 460 (2015) 766–771. [PMID: 25824047] 3.  Zhan, X., Bach, S.S., Hansen, N.L., Lunde, C. and Simonsen, H.T. Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS). Plant Physiol. Biochem. 96 (2015) 110–114. [PMID: 26248039]
[EC 4.2.3.229 created 2024]