The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 4.2.3.171     
Accepted name: (+)-corvol ether A synthase
Reaction: (2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate
Glossary: (+)-corvol ether A = (1R,4S,4aR,7R,8aR)-4,7-dimethyl-1-(propan-2-yl)decahydro-1,7-epoxynaphthalene
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-corvol ether A-forming]
Comments: The enzyme, which forms the sesquiterpene (+)-corvol ether A, has been reported from the bacterium Kitasatospora setae.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Rabe, P., Pahirulzaman, K.A. and Dickschat, J.S. Structures and biosynthesis of corvol ethers—sesquiterpenes from the actinomycete Kitasatospora setae. Angew. Chem. Int. Ed. Engl. 54 (2015) 6041–6045. [PMID: 25809275]
2.  Rabe, P., Janusko, A., Goldfuss, B. and Dickschat, J.S. Experimental and theoretical studies on corvol ether biosynthesis. Chembiochem. 17 (2016) 146–149. [PMID: 26635093]
3.  Rinkel, J., Rabe, P., Garbeva, P. and Dickschat, J.S. Lessons from 1,3-hydride shifts in sesquiterpene cyclizations. Angew. Chem. Int. Ed. Engl. 55 (2016) 13593–13596. [PMID: 27666571]
[EC 4.2.3.171 created 2017]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald