EC |
4.2.3.150 |
Accepted name: |
cembrene A synthase |
Reaction: |
geranylgeranyl diphosphate = (R)-cembrene A + diphosphate |
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For diagram of cembrene and related diterpenoids, click here |
Glossary: |
cembrene A = (1E,5E,9E,12R)-1,5,9-trimethyl-12-(propan-2-en-2-yl)cyclotetradeca-1,5,9-triene |
Other name(s): |
DtcycB (gene name) |
Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase [(R)-cembrene-A-forming] |
Comments: |
Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol. See EC 4.2.3.149, nephthenol synthase and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. ChemBioChem 14 (2013) 316–321. [DOI] [PMID: 23386483] |
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[EC 4.2.3.150 created 2014] |
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