The Enzyme Database

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EC 4.2.3.145     
Accepted name: ophiobolin F synthase
Reaction: (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate
For diagram of biosynthesis of diterpenoids from ent-copalyl diphosphate, click here and for diagram of sesterterpenoids biosynthesis, click here
Systematic name: (2E,6E,10E,14E)-geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, ophiobolin-F-forming)
Comments: Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Chiba, R., Minami, A., Gomi, K. and Oikawa, H. Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus. Org. Lett. 15 (2013) 594–597. [PMID: 23324037]
[EC 4.2.3.145 created 2014]
 
 


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