EC |
4.2.3.143 |
Accepted name: |
kunzeaol synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate + H2O = kunzeaol + diphosphate |
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For diagram of germacrene sesquiterpenoid biosynthesis, click here |
Glossary: |
kunzeaol = 6β-hydroxygermacra-1(10),4-diene = (1R,2E,6E,10R)-3,7-dimethyl-10-isopropylcyclodeca-2,6-dienol |
Other name(s): |
TgTPS2 (gene name) |
Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (kunzeaol-forming) |
Comments: |
Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Pickel, B., Drew, D.P., Manczak, T., Weitzel, C., Simonsen, H.T. and Ro, D.K. Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin. Biochem. J. 448 (2012) 261–271. [DOI] [PMID: 22938155] |
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[EC 4.2.3.143 created 2013] |
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