The Enzyme Database

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EC 4.2.3.143     
Accepted name: kunzeaol synthase
Reaction: (2E,6E)-farnesyl diphosphate + H2O = kunzeaol + diphosphate
For diagram of germacrene sesquiterpenoid biosynthesis, click here
Glossary: kunzeaol = 6β-hydroxygermacra-1(10),4-diene = (1R,2E,6E,10R)-3,7-dimethyl-10-isopropylcyclodeca-2,6-dienol
Other name(s): TgTPS2 (gene name)
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (kunzeaol forming)
Comments: Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Pickel, B., Drew, D.P., Manczak, T., Weitzel, C., Simonsen, H.T. and Ro, D.K. Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin. Biochem. J. 448 (2012) 261–271. [PMID: 22938155]
[EC 4.2.3.143 created 2013]
 
 


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