The Enzyme Database

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EC 4.2.3.139     
Accepted name: valerena-4,7(11)-diene synthase
Reaction: (2E,6E)-farnesyl diphosphate = valerena-4,7(11)-diene + diphosphate
For mechanism, click here
Glossary: valerena-4,7(11)-diene = (4S,7R,7aR)-3,7-dimethyl-4-(2-methylprop-1-en-1-yl)-2,4,5,6,7,7a-hexahydro-1H-indene
Other name(s): VoTPS2; VoTPS7
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, valerena-4,7(11)-diene-forming)
Comments: Isolated from the plant Valeriana officinalis (valerian). Note that due to a different numbering system the product is also known as valerena-1,10-diene.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Pyle, B.W., Tran, H.T., Pickel, B., Haslam, T.M., Gao, Z., Macnevin, G., Vederas, J.C., Kim, S.U. and Ro, D.K. Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). FEBS J. 279 (2012) 3136–3146. [PMID: 22776156]
2.  Yeo, Y.S., Nybo, S.E., Chittiboyina, A.G., Weerasooriya, A.D., Wang, Y.H., Gongora-Castillo, E., Vaillancourt, B., Buell, C.R., DellaPenna, D., Celiz, M.D., Jones, A.D., Wurtele, E.S., Ransom, N., Dudareva, N., Shaaban, K.A., Tibrewal, N., Chandra, S., Smillie, T., Khan, I.A., Coates, R.M., Watt, D.S. and Chappell, J. Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. J. Biol. Chem. 288 (2013) 3163–3173. [PMID: 23243312]
[EC 4.2.3.139 created 2012]
 
 


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