The Enzyme Database

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Accepted name: Δ6-protoilludene synthase
Reaction: (2E,6E)-farnesyl diphosphate = Δ6-protoilludene + diphosphate
For diagram of bicyclic and tricyclic sesquiterpenoids derived from humuladienyl cation, click here
Glossary: Δ6-protoilludene = (4aS,7aS,7bR)-3,6,6,7b-tetramethyl-2,4,4a,5,6,7,7a,7b-octahydro-1H-cyclobuta[1,2-e]indene
Other name(s): 6-protoilludene synthase
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Δ6-protoilludene-forming)
Comments: Isolated from the fungus Armillaria gallica. Δ6-Protoilludene is the first step in the biosynthesis of the melleolides.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Engels, B., Heinig, U., Grothe, T., Stadler, M. and Jennewein, S. Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. J. Biol. Chem. 286 (2011) 6871–6878. [PMID: 21148562]
[EC created 2012]

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