The Enzyme Database

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EC 4.2.3.129     
Accepted name: (+)-sativene synthase
Reaction: (2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate
For diagram of cadinane sesquiterpenoid biosynthesis, click here
Other name(s): cop4
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-sativene-forming)
Comments: Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-δ-cadinene, β-copaene, β-cubebene, and traces of several other sequiterpenoids. See EC 4.2.3.13, (+)-δ-cadinene synthase, EC 4.2.3.127, β-copaene synthase, and EC 4.2.3.128, β-cubebene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181–1195. [PMID: 19400802]
2.  Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. Chembiochem. 11 (2010) 1093–1106. [PMID: 20419721]
3.  Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723–7733. [PMID: 20889795]
[EC 4.2.3.129 created 2012]
 
 


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