| EC |
4.2.3.128 |
| Accepted name: |
β-cubebene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = β-cubebene + diphosphate |
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For diagram of cadinane sesquiterpenoid biosynthesis, click here |
| Other name(s): |
cop4; Mg25 |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, β-cubebene-forming) |
| Comments: |
Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-δ-cadinene, β-copaene, (+)-sativene and traces of several other sequiterpenoids [2-4]. It is found in many higher plants such as Magnolia grandiflora (Southern Magnolia) together with germacrene A [1]. See EC 4.2.3.13, (+)-δ-cadinene synthase, EC 4.2.3.127, β-copaene synthase, EC 4.2.3.129, (+)-sativene synthase, and EC 4.2.3.23, germacrene A synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Lee, S. and Chappell, J. Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora. Plant Physiol. 147 (2008) 1017–1033. [DOI] [PMID: 18467455] |
| 2. |
Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181–1195. [DOI] [PMID: 19400802] |
| 3. |
Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. ChemBioChem 11 (2010) 1093–1106. [DOI] [PMID: 20419721] |
| 4. |
Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723–7733. [DOI] [PMID: 20889795] |
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| [EC 4.2.3.128 created 2012] |
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