Accepted name: α-muurolene synthase
Reaction: (2E,6E)-farnesyl diphosphate = α-muurolene + diphosphate
Other name(s): Cop3
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-muurolene-forming)
Comments: The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and γ-muurolene, see EC, germacrene-A synthase and EC, γ-muurolene synthase.
1.  Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181–1195. [PMID: 19400802]
2.  Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723–7733. [PMID: 20889795]
[EC created 2012]

Data © 2001–2018 IUBMB
Web site © 2005–2018 Andrew McDonald