| EC |
4.2.3.118 |
| Accepted name: |
2-methylisoborneol synthase |
| Reaction: |
(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate |
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For diagram of bornane and related monoterpenoids, click here and for diagram of reaction, click here |
| Other name(s): |
sco7700; 2-MIB cyclase; MIB synthase; MIBS |
| Systematic name: |
(E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming) |
| Comments: |
The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Wang, C.M. and Cane, D.E. Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor. J. Am. Chem. Soc. 130 (2008) 8908–8909. [DOI] [PMID: 18563898] |
| 2. |
Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc. Natl. Acad. Sci. USA 105 (2008) 7422–7427. [DOI] [PMID: 18492804] |
| 3. |
Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. Biosynthesis of 2-methylisoborneol in cyanobacteria. Environ. Sci. Technol. 45 (2011) 992–998. [DOI] [PMID: 21174459] |
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| [EC 4.2.3.118 created 2012] |
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