The Enzyme Database

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EC 4.2.3.118     
Accepted name: 2-methylisoborneol synthase
Reaction: (E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate
For diagram of bornane and related monoterpenoids, click here and for diagram of reaction, click here
Other name(s): sco7700; 2-MIB cyclase; MIB synthase; MIBS
Systematic name: (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming)
Comments: The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Wang, C.M. and Cane, D.E. Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor. J. Am. Chem. Soc. 130 (2008) 8908–8909. [PMID: 18563898]
2.  Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc. Natl. Acad. Sci. USA 105 (2008) 7422–7427. [PMID: 18492804]
3.  Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. Biosynthesis of 2-methylisoborneol in cyanobacteria. Environ. Sci. Technol. 45 (2011) 992–998. [PMID: 21174459]
[EC 4.2.3.118 created 2012]
 
 


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