The Enzyme Database

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EC 4.2.3.109     
Accepted name: (-)-sabinene synthase
Reaction: geranyl diphosphate = (-)-sabinene + diphosphate
For diagram of thujane monoterpenoid biosynthesis, click here
Glossary: (-)-sabinene = (1S,5S)-1-isopropyl-4-methylenebicyclo[3.1.0]hexane
Systematic name: geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-sabinene-forming]
Comments: Requires Mg2+. Isolated from Pinus contorta (lodgepole pine) as cyclase I [1] and from Conocephalum conicum (liverwort) [2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Savage, T.J., Hatch, M.W. and Croteau, R. Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase. J. Biol. Chem. 269 (1994) 4012–4020. [PMID: 8307957]
2.  Peters, R.J. and Croteau, R.B. Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases. Arch. Biochem. Biophys. 417 (2003) 203–211. [PMID: 12941302]
[EC 4.2.3.109 created 2012]
 
 


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