The Enzyme Database

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Accepted name: ent-isokaurene synthase
Reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate
For diagram of biosynthesis of diterpenoids from ent-copalyl diphosphate, click here and for diagram of ent-kaurene and ent-isokaurene, click here
Other name(s): OsKSL5i; OsKSL6
Systematic name: ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-isokaurene-forming)
Comments: Two enzymes of the rice sub-species Oryza sativa ssp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene. A variant of OsKSL5 from the sub-species Oryza sativa ssp. japonica produces ent-pimara-8(14),15-diene instead [cf. EC, ent-pimara-8(14),15-diene synthase].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Xu, M., Wilderman, P.R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N.M., Coates, R.M. and Peters, R.J. Functional characterization of the rice kaurene synthase-like gene family. Phytochemistry 68 (2007) 312–326. [DOI] [PMID: 17141283]
2.  Xu, M., Wilderman, P.R. and Peters, R.J. Following evolution’s lead to a single residue switch for diterpene synthase product outcome. Proc. Natl. Acad. Sci. USA 104 (2007) 7397–7401. [DOI] [PMID: 17456599]
[EC created 2012]

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