The Enzyme Database

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EC 4.2.3.100     
Accepted name: bicyclogermacrene synthase
Reaction: (2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate
For diagram of bicyclogermacrene and avermitilol biosynthesis, click here
Other name(s): Ov-TPS4
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming)
Comments: The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Crocoll, C., Asbach, J., Novak, J., Gershenzon, J. and Degenhardt, J. Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis. Plant Mol. Biol. 73 (2010) 587–603. [PMID: 20419468]
[EC 4.2.3.100 created 2012]
 
 


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