The Enzyme Database

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EC 4.2.1.91     
Accepted name: arogenate dehydratase
Reaction: L-arogenate = L-phenylalanine + H2O + CO2
For diagram of phenylalanine and tyrosine biosynthesis, click here
Other name(s): carboxycyclohexadienyl dehydratase; L-arogenate hydro-lyase (decarboxylating)
Systematic name: L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)
Comments: Also acts on prephenate and D-prephenyllactate. cf. EC 4.2.1.51, prephenate dehydratase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 76600-70-9
References:
1.  Fischer, R. and Jensen, R. Arogenate dehydratase. Methods Enzymol. 142 (1987) 495–502. [PMID: 3600377]
2.  Zamir, L.O., Tiberio, R., Devor, K.A., Sauriol, F., Ahmad, S. and Jensen, R.A. Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. J. Biol. Chem. 263 (1988) 17284–17290. [PMID: 2972718]
3.  Siehl, D.L. and Conn, E.E. Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) Moench. Arch. Biochem. Biophys. 260 (1988) 822–829. [PMID: 3124763]
[EC 4.2.1.91 created 1992, modified 2005]
 
 


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