The Enzyme Database

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EC 4.2.1.9     
Accepted name: dihydroxy-acid dehydratase
Reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
For diagram of isoleucine and valine biosynthesis, click here
Other name(s): acetohydroxyacid dehydratase; α,β-dihydroxyacid dehydratase; 2,3-dihydroxyisovalerate dehydratase; α,β-dihydroxyisovalerate dehydratase; dihydroxy acid dehydrase; DHAD; 2,3-dihydroxy-acid hydro-lyase
Systematic name: 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9024-32-2
References:
1.  Kanamori, M. and Wixom, R.L. Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves. J. Biol. Chem. 238 (1963) 998–1005. [PMID: 13962154]
2.  Myers, J.W. Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine. J. Biol. Chem. 236 (1961) 1414–1418. [PMID: 13727223]
[EC 4.2.1.9 created 1961]
 
 


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