The Enzyme Database

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EC 4.2.1.49     
Accepted name: urocanate hydratase
Reaction: 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O
Glossary: urocanate = (E)-3-(imidazol-4-yl)propenoate
Other name(s): urocanase; 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase
Systematic name: 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)
Comments: Contains tightly bound NAD+.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9014-58-8
References:
1.  Rétey, J. The urocanase story: a novel role of NAD+ as electrophile. Arch. Biochem. Biophys. 314 (1994) 1–16. [PMID: 7944380]
2.  Hassall, H. and Greenberg, D.M. Urocanase (beef liver). Methods Enzymol. 17B (1971) 84–88.
3.  Kaminskas, E., Kimhi, Y. and Magasanik, B. Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway. J. Biol. Chem. 245 (1970) 3536–3544. [PMID: 4990470]
4.  Swaine, D. The effect of substrate analogues on the activity of cat liver urocanase. Biochim. Biophys. Acta 178 (1969) 609–618. [PMID: 5784906]
[EC 4.2.1.49 created 1972, modified 2001]
 
 


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