The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 4.2.1.123     
Accepted name: tetrahymanol synthase
Reaction: tetrahymanol = squalene + H2O
For diagram of hopene biosynthesis, click here
Glossary: tetrahymanol = gammaceran-3β-ol
Other name(s): squalene—tetrahymanol cyclase
Systematic name: squalene hydro-lyase (tetrahymanol forming)
Comments: The reaction occurs in the reverse direction.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Saar, J., Kader, J.C., Poralla, K. and Ourisson, G. Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila. Biochim. Biophys. Acta 1075 (1991) 93–101. [PMID: 1892870]
2.  Giner, J.L., Rocchetti, S., Neunlist, S., Rohmer, M. and Arigoni, D. Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. Chem. Commun. (Camb.) (2005) 3089–3091. [PMID: 15959594]
[EC 4.2.1.123 created 2011]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald