The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 4.2.1.112     
Accepted name: acetylene hydratase
Reaction: acetaldehyde = acetylene + H2O
Other name(s): AH; acetaldehyde hydro-lyase
Systematic name: acetaldehyde hydro-lyase (acetylene-forming)
Comments: This is a non-redox-active enzyme that contains two molybdopterin guanine dinucleotide (MGD) cofactors, a tungsten centre and a cubane type [4Fe-4S] cluster [2].The tungsten centre binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket [2]. Ethylene cannot act as a substrate [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, UM-BBD, CAS registry number: 75788-81-7
References:
1.  Rosner, B.M. and Schink, B. Purification and characterization of acetylene hydratase of Pelobacter acetylenicus, a tungsten iron-sulfur protein. J. Bacteriol. 177 (1995) 5767–5772. [PMID: 7592321]
2.  Seiffert, G.B., Ullmann, G.M., Messerschmidt, A., Schink, B., Kroneck, P.M. and Einsle, O. Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase. Proc. Natl. Acad. Sci. USA 104 (2007) 3073–3077. [PMID: 17360611]
[EC 4.2.1.112 created 2007]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald