The Enzyme Database

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Accepted name: bile-acid 7α-dehydratase
Reaction: 7α,12α-dihydroxy-3-oxochol-4-enoate = 12α-hydroxy-3-oxochola-4,6-dienoate + H2O
For diagram of reaction, click here
Other name(s): 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase
Systematic name: 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase (12α-hydroxy-3-oxochola-4,6-dienoate-forming)
Comments: The enzyme from Eubacterium sp. strain VPI 12708 can also use 7α-hydroxy-3-oxochol-4-enoate as a substrate but not 7α,12α-dihydroxy-3-oxochol-5β-anoate, 3α,7α,12α-trihydroxychol-5β-anoate or 7β-hydroxy-3-oxochol-4-enoate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Dawson, J.A., Mallonee, D.H., Björkhem, I. and Hylemon, P.B. Expression and characterization of a C24 bile acid 7α-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli. J. Lipid Res. 37 (1996) 1258–1267. [PMID: 8808760]
[EC created 2005]

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