The Enzyme Database

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Accepted name: chorismate lyase
Reaction: chorismate = 4-hydroxybenzoate + pyruvate
For diagram of ubiquinol biosynthesis, click here
Other name(s): CL; CPL; UbiC
Systematic name: chorismate pyruvate-lyase (4-hydroxybenzoate-forming)
Comments: This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 157482-18-3
1.  Nichols, B.P. and Green, J.M. Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase. J. Bacteriol. 174 (1992) 5309–5316. [PMID: 1644758]
2.  Siebert, M., Severin, K. and Heide, L. Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Microbiology 140 (1994) 897–904. [PMID: 8012607]
3.  Meganathan, R. Ubiquinone biosynthesis in microorganisms. FEMS Microbiol. Lett. 203 (2001) 131–139. [PMID: 11583838]
[EC created 2007]

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