The Enzyme Database

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EC 4.1.3.3     
Accepted name: N-acetylneuraminate lyase
Reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate
Other name(s): N-acetylneuraminic acid aldolase; acetylneuraminate lyase; sialic aldolase; sialic acid aldolase; sialate lyase; N-acetylneuraminic aldolase; neuraminic aldolase; N-acetylneuraminate aldolase; neuraminic acid aldolase; N-acetylneuraminic acid aldolase; neuraminate aldolase; N-acetylneuraminic lyase; N-acetylneuraminic acid lyase; NPL; NALase; NANA lyase; acetylneuraminate pyruvate-lyase; N-acetylneuraminate pyruvate-lyase
Systematic name: N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Comments: Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-60-5
References:
1.  Comb, D.G. and Roseman, S. The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid. J. Biol. Chem. 235 (1960) 2529–2537. [PMID: 13811398]
2.  Schauer, R. Sialic acids. Adv. Carbohydr. Chem. Biochem. 40 (1982) 131–234. [PMID: 6762816]
[EC 4.1.3.3 created 1961]
 
 


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