The Enzyme Database

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EC 4.1.1.99     
Accepted name: phosphomevalonate decarboxylase
Reaction: ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2
For diagram of the archaeal mevalonate pathway, click here
Systematic name: ATP:phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Comments: The enzyme is part of the mevalonate pathway in archaea.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Vannice, J.C., Skaff, D.A., Keightley, A., Addo, J.K., Wyckoff, G.J. and Miziorko, H.M. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. J. Bacteriol. 196 (2014) 1055–1063. [PMID: 24375100]
[EC 4.1.1.99 created 2014]
 
 


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