The Enzyme Database

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EC 4.1.1.4     
Accepted name: acetoacetate decarboxylase
Reaction: acetoacetate + H+ = acetone + CO2
For diagram of mevalonate biosynthesis, click here
Other name(s): acetoacetic acid decarboxylase; acetoacetate carboxy-lyase
Systematic name: acetoacetate carboxy-lyase (acetone-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9025-03-0
References:
1.  Davies, R. Studies of the acetone-butanol fermentation. 4. Acetoacetic acid decarboxylase of Cl. acetobutylicum (BY). Biochem. J. 37 (1943) 230–238. [PMID: 16747621]
2.  Zerner, B., Coutts, S.M., Lederer, F., Waters, H.H. and Westheimer, F.H. Acetoacetate decarboxylase. Preparation of the enzyme. Biochemistry 5 (1966) 813–816. [PMID: 5911291]
3.  Ho, M.C., Menetret, J.F., Tsuruta, H. and Allen, K.N. The origin of the electrostatic perturbation in acetoacetate decarboxylase. Nature 459 (2009) 393–397. [PMID: 19458715]
[EC 4.1.1.4 created 1961]
 
 


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