The Enzyme Database

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EC 4.1.1.22     
Accepted name: histidine decarboxylase
Reaction: L-histidine = histamine + CO2
Other name(s): L-histidine decarboxylase; L-histidine carboxy-lyase
Systematic name: L-histidine carboxy-lyase (histamine-forming)
Comments: A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9024-61-7
References:
1.  Epps, H.M.R. Studies on bacterial amino-acid decarboxylases. 4. l(-)-Histidine decarboxylase from Cl. welchii type A. Biochem. J. 39 (1945) 42–46. [PMID: 16747851]
2.  Riley, W.O. and Snell, E.E. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry 7 (1968) 3520–3528. [PMID: 5681461]
3.  Rosenthaler, J., Guirard, B.M., Chang, G.W. and Snell, E.E. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. USA 54 (1965) 152–158. [PMID: 5216347]
[EC 4.1.1.22 created 1961]
 
 


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