| EC |
3.7.1.3 |
| Accepted name: |
kynureninase |
| Reaction: |
L-kynurenine + H2O = anthranilate + L-alanine |
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For diagram of tryptophan catabolism, click here |
| Systematic name: |
L-kynurenine hydrolase |
| Comments: |
A pyridoxal-phosphate protein. Also acts on 3′-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9024-78-6 |
| References: |
| 1. |
Jakoby, W.B. and Bonner, D.M. Kynureninase from Neurospora: purification and properties. J. Biol. Chem. 205 (1953) 699–707. [PMID: 13129248] |
| 2. |
Jakoby, W.B. and Bonner, D.M. Kynureninase from Neurospora: interactions of enzyme with substrates, coenzyme and amines. J. Biol. Chem. 205 (1953) 709–715. [PMID: 13129249] |
| 3. |
Knox, W.E. The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. Biochem. J. 53 (1953) 379–385. [PMID: 13032082] |
| 4. |
Wiss, O. and Weber, F. Die Reindarstellung der Kynureninase. Hoppe-Seyler's Z. Physiol. Chem. 304 (1956) 232–240. |
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| [EC 3.7.1.3 created 1965] |
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