The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.6.4.6     
Accepted name: vesicle-fusing ATPase
Reaction: ATP + H2O = ADP + phosphate
Systematic name: ATP phosphohydrolase (vesicle-fusing)
Comments: A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger’s syndrome.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
References:
1.  Confalonieri, F. and Duguet, M. A 200-amino acid ATPase module in search of a basic function. BioEssays 17 (1995) 639–650. [PMID: 7646486]
2.  Imamura, A., Tamura, S., Shimoyawa, N., Suzuki, Y., Zhang, Z., Tsukamoto, T., Orii, T., Kondo, N., Osumi, T. and Fujiki, Y. Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders. Hum. Mol. Genet. 7 (1998) 2089–2094. [PMID: 9817926]
3.  Babst, W., Wendland, B., Estepa, E.J. and Emr, S.D. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J. 17 (1998) 2982–2983. [PMID: 9606181]
[EC 3.6.4.6 created 2000]
 
 


Data © 2001–2014 IUBMB
Web site © 2005–2014 Andrew McDonald