ExplorEnz: EC 3.6.4.6

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3.6.4.6

Accepted name:

vesicle-fusing ATPase

Reaction:

ATP + H₂O = ADP + phosphate

Systematic name:

ATP phosphohydrolase (vesicle-fusing)

Comments:

A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger’s syndrome.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Confalonieri, F. and Duguet, M. A 200-amino acid ATPase module in search of a basic function. BioEssays 17 (1995) 639–650. [DOI] [PMID: 7646486]
2.	Imamura, A., Tamura, S., Shimoyawa, N., Suzuki, Y., Zhang, Z., Tsukamoto, T., Orii, T., Kondo, N., Osumi, T. and Fujiki, Y. Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders. Hum. Mol. Genet. 7 (1998) 2089–2094. [DOI] [PMID: 9817926]
3.	Babst, W., Wendland, B., Estepa, E.J. and Emr, S.D. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J. 17 (1998) 2982–2983. [DOI] [PMID: 9606181]

[EC 3.6.4.6 created 2000]