The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.6.3.54     
Accepted name: Cu+-exporting ATPase
Reaction: ATP + H2O + Cu+[side 1] = ADP + phosphate + Cu+[side 2]
Other name(s): CopA; ATP7A; ATP7B
Systematic name: ATP phosphohydrolase (Cu+-exporting)
Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 3.6.3.4, Cu2+-exporting ATPase, which mainly transports the divalent copper ion.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Fan, B. and Rosen, B.P. Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase. J. Biol. Chem. 277 (2002) 46987–46992. [PMID: 12351646]
2.  Banci, L., Bertini, I., Ciofi-Baffoni, S., D'Onofrio, M., Gonnelli, L., Marhuenda-Egea, F.C. and Ruiz-Duenas, F.J. Solution structure of the N-terminal domain of a potential copper-translocating P-type ATPase from Bacillus subtilis in the apo and Cu(I) loaded states. J. Mol. Biol. 317 (2002) 415–429. [PMID: 11922674]
3.  Mandal, A.K. and Arguello, J.M. Functional roles of metal binding domains of the Archaeoglobus fulgidus Cu+-ATPase CopA. Biochemistry 42 (2003) 11040–11047. [PMID: 12974640]
4.  Gonzalez-Guerrero, M. and Arguello, J.M. Mechanism of Cu+-transporting ATPases: soluble Cu+ chaperones directly transfer Cu+ to transmembrane transport sites. Proc. Natl. Acad. Sci. USA 105 (2008) 5992–5997. [PMID: 18417453]
5.  Lewis, D., Pilankatta, R., Inesi, G., Bartolommei, G., Moncelli, M.R. and Tadini-Buoninsegni, F. Distinctive features of catalytic and transport mechanisms in mammalian sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) and Cu+ (ATP7A/B) ATPases. J. Biol. Chem. 287 (2012) 32717–32727. [PMID: 22854969]
6.  Tadini-Buoninsegni, F., Bartolommei, G., Moncelli, M.R., Pilankatta, R., Lewis, D. and Inesi, G. ATP dependent charge movement in ATP7B Cu+-ATPase is demonstrated by pre-steady state electrical measurements. FEBS Lett. 584 (2010) 4619–4622. [PMID: 20965182]
7.  Mattle, D., Sitsel, O., Autzen, H.E., Meloni, G., Gourdon, P. and Nissen, P. On allosteric modulation of P-type Cu+-ATPases. J. Mol. Biol. 425 (2013) 2299–2308. [PMID: 23500486]
[EC 3.6.3.54 created 2013]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald