The Enzyme Database

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EC 3.6.3.5     
Accepted name: Zn2+-exporting ATPase
Reaction: ATP + H2O + Zn2+in = ADP + phosphate + Zn2+out
Other name(s): Zn(II)-translocating P-type ATPase; P1B-type ATPase; AtHMA4
Systematic name: ATP phosphohydrolase (Zn2+-exporting)
Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme also exports Cd2+ and Pb2+.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
References:
1.  Beard, S.J., Hashim, R., Membrillo-Hernández, J., Hughes, M.N. and Poole, R.K. Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase. Mol. Microbiol. 25 (1997) 883–891. [PMID: 9364914]
2.  Rensing, C., Mitra, B. and Rosen, B.P. The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase. Proc. Natl. Acad. Sci. USA 94 (1997) 14326–14331. [PMID: 9405611]
3.  Rensing, C., Sun, Y., Mitra, B. and Rosen, B.P. Pb(II)-translocating P-type ATPases. J. Biol. Chem. 273 (1998) 32614–32617. [PMID: 9830000]
4.  Mills, R.F., Francini, A., Ferreira da Rocha, P.S., Baccarini, P.J., Aylett, M., Krijger, G.C. and Williams, L.E. The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels. FEBS Lett. 579 (2005) 783–791. [PMID: 15670847]
5.  Eren, E. and Argüello, J.M. Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn2+ homeostasis. Plant Physiol. 136 (2004) 3712–3723. [PMID: 15475410]
[EC 3.6.3.5 created 2000, modified 2001, modified 2006]
 
 


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