The Enzyme Database

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EC 3.6.3.49     
Accepted name: channel-conductance-controlling ATPase
Reaction: ATP + H2O = ADP + phosphate
Systematic name: ATP phosphohydrolase (channel-conductance-controlling)
Comments: ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Chen, M. and Zhang, J.T. Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes. Mol. Membr. Biol. 13 (1996) 33–40. [PMID: 9147660]
2.  Tusnady, G.E., Bakos, E., Varadi, A. and Sarkadi, B. Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett. 402 (1997) 1–3. [PMID: 9013845]
3.  Sheppard, D.N. and Welsh, M.J. Structure and function of the CFTR chloride channel. Physiol. Rev. 79 (1999) S23–S45. [PMID: 9922375]
[EC 3.6.3.49 created 2000]
 
 


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