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Your query returned 1 entry. Printable version
EC | 3.6.1.69 | ||
Accepted name: | 8-oxo-(d)GTP phosphatase | ||
Reaction: | (1) 8-oxo-GTP + H2O = 8-oxo-GDP + phosphate (2) 8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate |
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Glossary: | 8-oxo-dGTP = 2′-deoxy-7,8-dihydro-8-oxoguanosine 5′-triphosphate | ||
Other name(s): | mutT1 (gene name) | ||
Systematic name: | 8-oxo-dGTP diphosphohydrolase | ||
Comments: | The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
References: |
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