ExplorEnz: EC 3.6.1.69

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3.6.1.69

Accepted name:

8-oxo-(d)GTP phosphatase

Reaction:

(1) 8-oxo-GTP + H₂O = 8-oxo-GDP + phosphate
(2) 8-oxo-dGTP + H₂O = 8-oxo-dGDP + phosphate

Glossary:

8-oxo-dGTP = 2′-deoxy-7,8-dihydro-8-oxoguanosine 5′-triphosphate

Other name(s):

mutT1 (gene name)

Systematic name:

8-oxo-dGTP diphosphohydrolase

Comments:

The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Patil, A.G., Sang, P.B., Govindan, A. and Varshney, U. Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance. J. Biol. Chem. 288 (2013) 11252–11262. [PMID: 23463507]

[EC 3.6.1.69 created 2019]