|
Your query returned 1 entry. Printable version
EC | 3.6.1.58 | ||||||||||||
Accepted name: | 8-oxo-dGDP phosphatase | ||||||||||||
Reaction: | (1) 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate (2) 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate |
||||||||||||
Glossary: | 8-oxo-dGDP = 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-diphosphate | ||||||||||||
Other name(s): | NUDT5; MTH3 (gene name); NUDT18 | ||||||||||||
Systematic name: | 8-oxo-dGDP phosphohydrolase | ||||||||||||
Comments: | The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
| ||||||||||||