EC |
3.6.1.52 |
Accepted name: |
diphosphoinositol-polyphosphate diphosphatase |
Reaction: |
diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate |
Other name(s): |
diphosphoinositol-polyphosphate phosphohydrolase; DIPP |
Systematic name: |
diphospho-myo-inositol-polyphosphate diphosphohydrolase |
Comments: |
This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Safrany, S.T., Caffrey, J.J., Yang, X., Bembenek, M.E., Moyer, M.B., Burkhart, W.A. and Shears, S.B. A novel context for the 'MutT′ module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J. 17 (1998) 6599–6607. [DOI] [PMID: 9822604] |
2. |
Caffrey, J.J., Safrany, S.T., Yang, X. and Shears, S.B. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family. J. Biol. Chem. 275 (2000) 12730–12736. [DOI] [PMID: 10777568] |
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[EC 3.6.1.52 created 2002] |
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