The Enzyme Database

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EC 3.5.4.8     
Accepted name: aminoimidazolase
Reaction: 4-aminoimidazole + H2O = imidazol-4-one + NH3
Other name(s): 4-aminoimidazole hydrolase; 4-aminoimidazole deaminase
Systematic name: 4-aminoimidazole aminohydrolase
Comments: Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9025-17-6
References:
1.  Rabinowitz, J.C. and Pricer, W.E. Purine fermentation by Clostridium cylindrosporum. V. Formiminoglycine. J. Biol. Chem. 222 (1956) 537–554. [PMID: 13367024]
2.  Freter, K., Rabinowitz, J.C. and Witkop, B. Labile Stoffwechselprodukte. V. Zur Biogenese des Formiminoglycins aus 4(5H)-imidazolon. Ann. Chem. 607 (1957) 174–187. (in German)
3.  Vogels, G.D. and Van der Drift, C. Degradation of purines and pyrimidines by microorganisms. Bacteriol. Rev. 40 (1976) 403–468. [PMID: 786256]
4.  DeMoll, E. and Auffenberg, T. Purine metabolism in Methanococcus vannielii. J. Bacteriol. 175 (1993) 5754–5761. [PMID: 8376322]
[EC 3.5.4.8 created 1961]
 
 


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