| EC |
3.5.4.37 |
| Accepted name: |
double-stranded RNA adenine deaminase |
| Reaction: |
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3 |
| Other name(s): |
ADAR; double-stranded RNA adenosine deaminase; dsRAD; dsRNA adenosine deaminase; DRADA1; double-stranded RNA-specific adenosine deaminase |
| Systematic name: |
double-stranded RNA adenine aminohydrolase |
| Comments: |
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
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| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Hough, R.F. and Bass, B.L. Purification of the Xenopus laevis double-stranded RNA adenosine deaminase. J. Biol. Chem. 269 (1994) 9933–9939. [PMID: 8144588] |
| 2. |
O'Connell, M.A., Gerber, A. and Keegan, L.P. Purification of native and recombinant double-stranded RNA-specific adenosine deaminases. Methods 15 (1998) 51–62. [DOI] [PMID: 9614652] |
| 3. |
Wong, S.K., Sato, S. and Lazinski, D.W. Substrate recognition by ADAR1 and ADAR2. RNA 7 (2001) 846–858. [PMID: 11421361] |
| 4. |
Macbeth, M.R., Schubert, H.L., Vandemark, A.P., Lingam, A.T., Hill, C.P. and Bass, B.L. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science 309 (2005) 1534–1539. [DOI] [PMID: 16141067] |
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| [EC 3.5.4.37 created 2013] |
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