The Enzyme Database

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EC 3.5.4.34     
Accepted name: tRNAAla(adenine37) deaminase
Reaction: adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3
Other name(s): ADAT1; Tad1p
Systematic name: tRNAAla(adenine37) aminohydrolase
Comments: The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Maas, S., Gerber, A.P. and Rich, A. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Proc. Natl. Acad. Sci. USA 96 (1999) 8895–8900. [PMID: 10430867]
2.  Gerber, A., Grosjean, H., Melcher, T. and Keller, W. Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. EMBO J. 17 (1998) 4780–4789. [PMID: 9707437]
3.  Keegan, L.P., Gerber, A.P., Brindle, J., Leemans, R., Gallo, A., Keller, W. and O'Connell, M.A. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Mol. Cell Biol. 20 (2000) 825–833. [PMID: 10629039]
[EC 3.5.4.34 created 2013]
 
 


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