The Enzyme Database

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EC 3.5.4.22     
Accepted name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase
Reaction: 1-pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-dioxopentanoate + NH3
Other name(s): HPC deaminase; 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
Systematic name: 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (ring-opening)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9054-77-7
References:
1.  Singh, R.M.M. and Adams, E. Enzymatic deamination of Δ1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (α-ketoglutaric semialdehyde). J. Biol. Chem. 240 (1965) 4344–4351. [PMID: 5845838]
2.  Singh, R.M.M. and Adams, E. Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline. J. Biol. Chem. 240 (1965) 4352–4356. [PMID: 5845839]
[EC 3.5.4.22 created 1976]
 
 


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