The Enzyme Database

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EC 3.5.3.7     
Accepted name: guanidinobutyrase
Reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea
For diagram of arginine catabolism, click here
Glossary: 4-aminobutanoate = γ-aminobutyrate = GABA
Other name(s): γ-guanidobutyrase; 4-guanidinobutyrate amidinobutyrase; γ-guanidinobutyrate amidinohydrolase; G-Base; GBH; guanidinobutyrate ureahydrolase
Systematic name: 4-guanidinobutanoate amidinohydrolase
Comments: Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9013-69-8
References:
1.  Mora, J., Tarrab, R., Martuscelli, J. and Soberón, G. Characteristics of arginases from ureotelic and non-ureotelic animals. Biochem. J. 96 (1965) 588–594. [PMID: 5862400]
2.  Thoai, N.V., Thome-Beau, F. and Olomucki, A. [Induction and specificity of enzymes of the new catabolic arginine pathway] Biochim. Biophys. Acta 115 (1966) 73–80. [PMID: 5936244]
3.  Yorifuji, T., Kato, M., Kobayashi, T., Ozaki, S. and Ueno, S. 4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp ATCC 14676: purification to homogeneity and properties. Agric. Biol. Chem. 44 (1980) 1127–1134.
4.  Yorifuji, T., Kobayashi, T., Tabuchi, A., Shiritani, Y. and Yonaha, K. Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping. Agric. Biol. Chem. 47 (1983) 2825–2830.
[EC 3.5.3.7 created 1972]
 
 


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