The Enzyme Database

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Accepted name: N1-aminopropylagmatine ureohydrolase
Reaction: N1-aminopropylagmatine + H2O = spermidine + urea
For diagram of spermidine biosynthesis, click here
Systematic name: N1-aminopropylagmatine amidinohydrolase
Comments: The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Ohnuma, M., Terui, Y., Tamakoshi, M., Mitome, H., Niitsu, M., Samejima, K., Kawashima, E. and Oshima, T. N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus. J. Biol. Chem. 280 (2005) 30073–30082. [PMID: 15983049]
2.  Morimoto, N., Fukuda, W., Nakajima, N., Masuda, T., Terui, Y., Kanai, T., Oshima, T., Imanaka, T. and Fujiwara, S. Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis. J. Bacteriol. 192 (2010) 4991–5001. [PMID: 20675472]
[EC created 2013]

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